A comparative biodistribution and toxicity study of single and multi-component nanomaterials: NMs: TiO2, SiC, and SiC@TiO2
Publication category: Journal Article
Publication date: 20 February, 2026
Authors: Wenting Zhang, Muhammad Daniyal Ghouri, Magda Blosi, Ying Liu, Chunying Chen, Flemming R. Cassee, Rong Cai
Abstract: With the increasing integration of nanomaterials (NMs) into daily life, their technological advantages have become evident. However, their intricate interactions with biological systems introduce complexities that can lead to unpredictable toxicological outcomes. This study investigated the in vivo toxicokinetics and toxicodynamics of single- and multi-component NMs composed of silicon carbide (SiC), titanium dioxide (TiO2), and a SiC@TiO2 composite, along with a physical mixture of SiC and TiO2 in the same ratio as the composite. Rats were exposed to these materials via single intratracheal instillation, and biological responses were assessed over time (1 h to 28 days) to identify the no-observed-adverse-effect level (NOAEL).
